apparent diffusion coefficient  (Wolters Kluwer Health)

Journal: bioRxiv

Article Title: Multimodal Characterization and Evolution of Malonate-induced Stroke Model: Advanced MRI, Histology-Molecular Profiling

doi: 10.1101/2025.10.22.684053

Figure Lengend Snippet: A. The percentage of viable and necrotic tissue with respect to the total lesion volume. B.The evolution of vessel radius (R). C. Blood volume fraction (BVF). D. Oxygen saturation (StO 2 ) E. Signal enhancement F. Apparent diffusion coefficient (ADC) observed by MRI at D4, D7, D14, D28, and D56 after ischemic injury by malonate injection. n=5 at D4, n=13 at D7, n=8 at D14, n=8 at D28 and n=7 at D56. Data is represented by medians and IQR. *: 0.03>p>0.01, **: 0.005>p>0.001, ***: 0.0005>p>0.0001, ****: p<0.0001 vs contralateral hemisphere, paired non-parametric Mann-Whitney test.

Article Snippet: Apparent diffusion coefficient (ADC) maps were automatically computed on the Bruker scanner as the means of the ADCs observed in each of three orthogonal directions.

Techniques: Diffusion-based Assay, Injection, MANN-WHITNEY

Journal: Journal for immunotherapy of cancer

Article Title: Neoadjuvant toripalimab combined with axitinib in patients with locally advanced clear cell renal cell carcinoma: a single-arm, phase II trial.

doi: 10.1136/jitc-2023-008475

Figure Lengend Snippet: Figure 4 (A and B) MRI and pathological alterations in patients before and after axitinib plus toripalimab administration. (A) Example of highly immune infiltrated tumor; (B) example of minimally infiltrated tumor. ADC: apparent diffusion coefficient. (C) Baseline biomarkers correlated with response to treatment analyzed by NanoString IO 360. The volcano plot displays differential gene expression at baseline. (D). Relative fraction of tumor-infiltrating lymphocytes. Each row represents an immune cell subpopulation estimated by multiplexed immunofluorescence, including the density of PD1+ cells, PD1+CD8+ cells, PD- L1+ cells, PD-L1+CK+ cells, CD3+ cells, CD4+ cells, CD8+ cells, CD20+ cells, CD56+ cells, FOXP3+ cells, CD68+CD163- macrophage cells M1, CD68+CD163+ macrophage cells M2. The relative infiltrations of each lymphocyte subpopulations were normalized into a z-score. (E). Comparison of density levels of tumor-infiltrating PD1+ cells, PD1+CD8+ cells, PD-L1+ cells, PD- L1+CK+ cells between partial response (PR) and SD patients. *, p<0.05. (F). Comparison of density levels of tumor-infiltrating CD3+ cells, CD4+ cells, CD8+ cells, CD20+ cells, CD56+ cells, FOXP3+ cells, M1 macrophages, and M2 macrophages between PR and SD patients. No significant differences were found. (G). Representative multiplexed immunofluorescence images showing the simultaneous staining of panel 1 (left): DAPI (blue), CD8+ (red), PD-1+ (green), PD-L1+ (yellow), and CK (gray). Panel 2 (right): DAPI (blue), CD3+ (red), CD4+ (green), FOXP3+ (yellow), CD20+ (orange), and CK (gray) in PR (up) and SD (bottom) patients. Scale bar: 20 µm.

Article Snippet: ADC: apparent diffusion coefficient. (C) Baseline biomarkers correlated with response to treatment analyzed by NanoString IO 360.

Techniques: Diffusion-based Assay, Gene Expression, Immunofluorescence, Comparison, Staining